Vaccines up to 94 pc effective against hospitalisation versus Delta variant

Vaccines are more effective at preventing hospitalisation against the Indian/Delta variant than they were against previous types, once people are double-jabbed, new data shows.

Real world data shows the Pfizer/BioNTech vaccine is 94 per cent effective against hospital admission from the variant after one dose, rising to 96 per cent after two jabs.

The Oxford/AstraZeneca vaccine was found to be 71 per cent effective against hospital admission after one dose, rising to 92 per cent after two jabs.

In both cases, two doses had a greater impact preventing hospitalisations than was the case with the Kent variant. 

Ministers said the findings were “extremely encouraging” – showing jabs “continuing to help break the link” between the variant and severe disease. 

Public Health England tracked more than 14,000 people with the Indian/Delta variant to see how effective vaccines are in protecting against hospitalisation.

Ministers have said this measure is “absolutely critical” in the debate about easing restrictions, amid concern about the impact of rising cases on hospital pressures. 

It follows concern that vaccines are less able to prevent infection with Indian variant, the dominant strain in the country, with one jab preventing just a third of symptomatic cases. 

The new analysis found that one dose of Pfizer prevented 94 per cent of hospitalisations with the Indian variant, compared with 83 per cent from the Kent type. At two doses, it stopped 96 per cent of cases, against 95 per cent with the previous strain. 

One dose of Astra Zeneca fared better against the Kent variant than the Indian type, blocking 76 per cent of hospitalisations, rather than 71 per cent. 

But the result after two doses was significantly better against the new strain, preventing 92 per cent of hospitalisations, rather than 86 per cent. 

Effectiveness of vaccines against hospitalisation (PHE)

Vaccines Minister Nadhim Zahawi said: “It is extremely encouraging to see today’s research showing that vaccines are continuing to help break the link between hospitalisation and the Delta variant after one dose, and particularly the high effectiveness of two doses. 

“If you’re getting the call to bring forward your second dose appointment, do not delay. Get the second jab so you can benefit from the fullest possible protection.”

Dr Mary Ramsay, Head of Immunisation at PHE, said: “These hugely important findings confirm that the vaccines offer significant protection against hospitalisation from the Delta variant.

“The vaccines are the most important tool we have against covid-19. Thousands of lives have already been saved because of them.

“It is absolutely vital to get both doses as soon as they are offered to you, to gain maximum protection against all existing and emerging variants.”

How many more could we vaccinated with the delay to June 21?

The analysis included 14,019 cases of the Delta variant – 166 of whom were hospitalised – between 12 April and 4 June, looking at emergency admissions in England.

PHE said further work is underway to establish the level of protection vaccines offer against mortality, but said it was expected to be high. 

Health and Social Care Secretary Matt Hancock said: “Our UK vaccination programme continues at pace and has already saved thousands of lives. It is our way out of this pandemic.

“This evidence of the effectiveness of two doses against variants shows just how crucial it is to get your second jab.

"If you have had your first dose but haven’t booked your second yet – please do so. It will help save lives and boost us on the road to recovery.”

PHE estimates suggest the vaccination programme has so far prevented 14,000 deaths and around 42,000 hospitalisations of older people in England.

‘Vaccines highly effective’

A separate study from Scotland has found that the risk of hospitalisation from the Indian variant is cut by 70 per cent for people who have been fully vaccinated.

The nationwide data reveals that although the risk of being admitted to hospital is doubled for people catching the Indian mutation, the vaccines are still very effective.

The study by the University of Edinburgh and Public Health Scotland (PHS) suggested vaccines were more effective in protecting against the Kent strain. 

However it also found  "very few" over-65s testing positive for Covid, suggesting the jabs are protecting the most vulnerable.

The Scottish team calculated that for people who had two doses or who had their first dose at least four weeks ago, the risk of being hospitalised with the Kent variant was reduced by 72 per cent and the Indian variant by 62 per cent. 

In community cases at least two weeks after the second dose, the Pfizer/BioNTech jab was found to provide 79 per cent protection against infection from the Indian variant, compared with 92 per cent against the Kent strain.

The Oxford/AstraZeneca vaccine offered 60 per cent protection against infection with the Indian variant compared with 73 per cent for the Kent variant.

Dr Jim McMenamin, the national Covid-19 incident director at PHS, said: "We do appear to show that delta variant does increase the risk of hospitalisation. However, what we are able to see is that our vaccines are still highly effective. 

"These results provide early encouragement that two doses of either Pfizer/BioNTech or Oxford/AstraZeneca vaccines significantly reduce the risk of infection against both the alpha or new delta variants.

The findings are published as a research letter in The Lancet.

Researchers said a delay to the June 21 reopening would mean more people could get their second jab and gain further protection. Prof Aziz Sheikh, director of the Usher Institute and professor of primary care research and development at the University of Edinburgh, said: “Getting people second doses and giving people reasonable amounts of time is key here really. 

"If there is a delay, that will give us the opportunity to widen coverage, and for those who have only got one dose what we want is a period of time where people can maximise their immune response.” 

Leave a Reply

Your email address will not be published. Required fields are marked *